Fenbendazole, first developed as a broad-spectrum benzimidazole for animals, is seeing growing exploration into its potential for cancer treatment. While most anthelmintic medications are based off of animal research and studies, there are many parallels between parasitic cells and tumor cells that may indicate antiparasitic drugs might be effective in human cancer treatment as well.
Aside from its anthelmintic properties, fenbendazole has shown a strong ability to kill cancerous cells in laboratory experiments. It works by binding to -tubulin and stopping the polymerization of tubulin dimers which leads to cell cycle arrest and death. Fenbendazole also interferes with the phosphorylation of key tumor suppressor genes like p53.
One of the most significant features of fenbendazole is that it does not utilize a drug efflux mechanism like p-glycoproteins. This means that tumors will not be able to expel anti-cancer drugs from the inside of them, as is seen with many chemotherapy medications after chemo-resistance develops. Despite this, there is still no clinical proof that fenbendazole can help cure cancer, but the possibility remains intriguing.
Taking fenbendazole 222mg capsules for humans can be a complicated process due to the fact that dosage is largely dependent on a person or animal’s weight and unique health factors. For this reason, the best way to determine a proper dosage is through the use of a veterinarian.
It is also important to note that although fenbendazole does not come with a lot of adverse side effects, it can increase liver enzyme levels in some people and should be taken alongside supplements such as NAC to mitigate any negative effects. Additionally, if you are taking fenbendazole, it is important to follow your doctor’s instructions for dosing as it can have serious consequences if not administered correctly. fenbendazole 222mg capsules for humans